Developmental potential of murine keratinocyte stem cells [ 2001 - 2003 ]

Research Grant

Researchers: A/Pr Pritinder Kaur (Principal investigator) ,  A/Pr Ivan Bertoncello

Brief description The stem cells of the epidermis or outer lining of the skin are an important group of cells with a role in normal cell replenishment, in wound healing and in skin disorders such as psoriasis and cancer. These primitive cells remain in the skin during the lifetime of an individual and are responsible for the production of mature, functional cells that form a protective barrier against the environment and pathogens. We have recently developed a strategy for the isolation of stem cells of the skin which places us in a unique position to further study these cells and determine possible therapeutic approaches for the future. The aims of this project encompass testing the potency of skin stem cells (i) to reform complex structures such as a mature epidermis, hair follicles and sebaceous glands; and (ii) to give rise to cells from other tissues such as muscle and liver. A final aim of this project is to dissect the complexity of the stem cell compartment further to gain insights into how normal skin growth is regulated.

Funding Amount $AUD 212,036.72

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant