Development of small molecule inhibitors of IRAP - potential use for the treatment of memory disorders [ 2007 - 2007 ]

Research Grant

Researchers: A/Pr Siew Yeen Chai (Principal investigator) ,  Dr Anthony Albiston ,  Prof Frederick Mendelsohn

Brief description This research project provides proof of concept that IRAP is a suitable target for use in the development of a new class of clinically valuable cognitive-enhancing agents. We have recently Identified a family of small molecule compounds that inhibited the catalytic activity of the enzyme using a molecule model of IRAP to screen virtual libraries. This research proposal aims to validate that this family of compounds have memory-enhancing properties by acting specifically on IRAP. At the conclusion of this project, we will have elucidated important information on the specificity of the memory effects and the structure activity relationship of this family of compounds. We will have identified and characterised a lead compound for development into a new class of cognitive enhancers.

Funding Amount $AUD 195,450.00

Funding Scheme NHMRC Development Grants

Notes Development Grant