grant

Development of small molecule IRAP inhibitors for treating memory deficits [ 2008 - 2010 ]

Also known as: Development of drugs that block IRAP activity as anti-dementia agents.

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/520695]

Researchers: A/Pr Siew Yeen Chai (Principal investigator) ,  Dr Anthony Albiston ,  Prof Frederick Mendelsohn ,  Prof Philip Thompson

Brief description We have identified a series of small molecule compounds based on their ability to inhibit the catalytic activity of a protein, IRAP using a computer model of IRAP to screen chemical libraries. This research proposal aims to investigate the properties of these compounds and their ability to treat Alzheimer's dementia. At the conclusion of this project, we will have 2 families of lead compounds suitable for development into a new class of therapeutic agents for treating Alzheimer's disease.

Funding Amount $AUD 369,898.62

Funding Scheme NHMRC Development Grants

Notes Development Grant

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Subjects
Biomedical and Clinical Sciences | Medical Biochemistry - Inorganic Elements and Compounds | Medical Biochemistry and Metabolomics | dementia | diabetes | diabetes mellitus | drug development | glucose homeostasis | learning and memory | memory-related disorders | metabolic disorders |
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