Development of purine nucleoside phosphonates as anti-malarial drugs targeting nuceloside synthesis in Plasmodium [ 2009 - 2012 ]

Research Grant

Researchers: A/Pr Luke Guddat (Principal investigator) ,  A/Pr Lieve Naesens ,  Dr Tina Skinner-Adams ,  E/Pr John De Jersey ,  Prof Antonin Holy
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Brief description Malaria is one of the most serious infectious diseases today. Because of its location in a malaria endemic region, the tropical regions (above 19 S in latitude) of Australia face an emerging threat. The causative agent of the disease is the parasite, Plasmodium. Because of increasing resistance to existing medicines, new drugs are now needed. The drugs we will develop target the parasites replication cycle and are related in structure to those in use to treat viral infections including AIDS.

Funding Amount $AUD 428,917.10

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant