Development of novel anti-cancer and immunosuppressive drugs derived from pineapple stems [ 2005 - 2007 ]

Research Grant

Researchers: Dr Christian Engwerda (Principal investigator) ,  Dr Tracey Mynott

Brief description We have discovered two molecules from pineapple stems that show anti-tumour activity in laboratory studies. One molecule, called ananain, blocks a cancer causing protein called Ras, which is defective in approximately 30% of all cancers. The other molecule, called canizain, stimulates the bodies own immune system to target and kill cancer cells. The proposed research seeks to provide proof of concept of the use of ananain and canizain as drug development targets. Once this early proof of principle phase has been completed, we believe that ananain and canizain would be extremely attractive targets for further investment by a major pharmaceutical company.

Funding Amount $AUD 469,500.00

Funding Scheme NHMRC Development Grants

Notes Development Grant