Development of a New Specific Immunosuppressive Monoclonal Antibody to Advance Transplantation [ 2016 - 2018 ]

Research Grant

Researchers: Prof Derek Hart (Principal investigator) ,  A/Pr Georgina Clark ,  A/Pr Stephen Larsen ,  Prof Annemarie Hennessy ,  Prof Barbara Fazekas De St Groth
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Brief description Current nonspecific immunosuppressive agents compromise post transplant protective responses, including the anti-tumour effect of a bone marrow transplant. We have developed an antibody (3C12C), that targets CD83 on activated dendritic cells as a new, more specific, immunosuppressive strategy. We will work with our commercial partner to develop the patented antibody as a new imunosuppressive agent, which retains anti-viral and anti-cancer responses. This would be a major advance for patients.

Funding Amount $AUD 754,032.87

Funding Scheme Development Grants

Notes Development Grant