Development of Iron Complexes for the Treatment of FriedreichÍs Ataxia & the Role of Frataxin in Iron Metabolism [ 2011 - 2014 ]

Research Grant

Researchers: Prof Des Richardson (Principal investigator) ,  Dr Yohan Suryo Rahmanto ,  Prof Prem Ponka

Brief description Friedreich's ataxia (FA) is a neuro- & cardio-degenerative disease where there is an accumulation of toxic iron (Fe) in the mitochondrion. Work from our current NHMRC grant showed iron plays a significant role in FA pathology In fact, the CIs dissected the mechanisms of mitochondrial iron-loading & have published 8 papers in high impact journals with 3 papers in PNAS USA in the last 2 yrs Understanding of this process has led to the design of rationalised drugs for FA This work in this Renewal could lead to novel therapies for FA

Funding Amount $AUD 616,142.99

Funding Scheme Project Grants

Notes Standard Project Grant