Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/1017594]Researchers: A/Pr Daniel Christ (Principal investigator) , Prof Samuel Breit (Principal investigator) , Prof David Brown
Brief description Severe starvation and weight loss (cachexia) is a complication that affects about one quarter of cancer patients. In many this is due to the cancer producing a powerfula appetite suppressive protein called MIC-1/GDF15. This weight loss can be prevented by blocking the protein with an antibody drug. We have already shown that we can treat mice in this way by using a mouse antibody. We now aim to engineer these antibodies by making them more human-like. This will allow us to treat weight loss in human cancer patients.
Funding Amount $AUD 587,349.39
Funding Scheme Development Grants
Notes Development Grant
- nhmrc : 1017594
- PURL : https://purl.org/au-research/grants/nhmrc/1017594