Development of functional liver tissue engineered from murine hepatocyte or liver progenitor cell spheroids to correct liver disease [ 2012 - 2015 ]

Research Grant

Researchers: A/Pr Geraldine Mitchell (Principal investigator) ,  Dr Heidi Peters ,  E/Pr Wayne Morrison ,  Prof George Yeoh

Brief description Many patients suffering from severe liver disease require a liver transplant, but due to a shortage of liver donors, many die prior to liver transplantation. This study investigates novel methods of growing liver tissue from mature liver cells called hepatocytes, or, liver stem cells implanted in a plastic chamber in mice with acute and chronic liver disease. It is anticipated that new liver tissue will grow in the chamber, the mice will be cured, and that this technique can be translated to humans with liver disease.

Funding Amount $AUD 459,482.07

Funding Scheme Project Grants

Notes Standard Project Grant