grant

Development of endogenous granulocyte colony stimulating factor (G-CSF) antagonism as a new therapeutic approach to inflammatory disease [ 2012 - 2015 ]

Also known as: G-CSF blockade as a therapy for inflammatory diseases

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1034594]

Researchers: Dr Gabrielle Goldberg (Principal investigator)

Brief description Neutrophils play a pivotal role in inflammatory diseases including rheumatoid arthritis (RA). G-CSF is a growth factor that is important to neutrophil survival and function. We have shown that in the absence of G-CSF the incidence and severity of experimental autoimmune arthritis are reduced. We will investigate the mechanisms by which this occurs as well as studying the effects of G-CSF blockade on function and survival of human neutrophils from healthy donors and RA patients.

Funding Amount $AUD 401,561.47

Funding Scheme Career Development Fellowships

Notes Industry CDF

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Identifiers
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ACN 633 798 857