grant

Development of dynamin inhibitors as novel therapies for epilepsy [ 2009 - 2011 ]

Also known as: Two new targets for antiepileptic drug development

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/571076]

Researchers: Prof Phillip Robinson (Principal investigator) ,  Prof Adam Mccluskey ,  Prof Terence O'Brien

Brief description Epilepsy affects 1% of people, but 30% do not respond to current anti-epileptic drugs (AEDs). Traditional drug discovery has not improved this situation. Our team discovered two exciting new targets for design of better AEDs. One of them blocks seizure in animals. Our aim is to determine how well they work in true animal models of epilepsy. If successful, this will accelerate development of new AEDs with less side-effects, benefiting large sectors of the Australian community.

Funding Amount $AUD 903,376.54

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Anti-Convulsant | Anti-epileptic drugs | Biomedical and Clinical Sciences | Dynamin | Epilepsy | Medical Biochemistry and Metabolomics | Medical Biochemistry and Metabolomics Not Elsewhere Classified | Neuronal burst firing | New epilepsy treatments | Pharmacodynamics | True models of epilepsy |
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