Developing diagnostics and therapeutics for preeclampsia: targeting a novel placental specific sFlt-1 variant [ 2014 - 2016 ]

Research Grant

Researchers: Prof Stephen Tong (Principal investigator) ,  Dr Kirsten Palmer ,  Dr Tu'Uhevaha Kaitu'U-Lino

Brief description Preeclampsia is a dreaded disease of pregnancy, globally responsible for thousands of deaths of mothers and babies. It is caused by a protein called sFlt-1 leaking out of the placenta and attacking the mothers organs. Recently, a new sflt-1 subtype was discovered that is specific to the placenta. It may be the key disease causing toxin in preeclampsia. We will target this placental specific sFlt-1 to generate diagnostics to predict preeclampsia, and explore novel ways to block the toxic effects of sFlt-1 as a strategy to develop drugs.

Funding Amount $AUD 722,283.23

Funding Scheme Project Grants

Notes Standard Project Grant