Determining the tumour suppressor function of the MCC gene and its significance to treatment outcomes in colorectal cancer. [ 2012 - 2015 ]

Research Grant

Researchers: A/Pr Maija Kohonen-Corish (Principal investigator) ,  Dr Laurent Pangon ,  Prof Jane Dahlstrom ,  Prof Stephen Clarke

Brief description This project analyses the early stages of bowel cancer, where we have discovered a new gene defect. We want to determine how the MCC gene defect promotes tumorigenesis and how it affects treatment outcomes, by studying a novel mouse model of bowel cancer. This will determine which cellular functions are altered following loss of MCC in bowel tumours and if the MCC defect can be exploited to identify patients who would benefit from radiotherapy or specific chemotherapies.

Funding Amount $AUD 620,716.41

Funding Scheme Project Grants

Notes Standard Project Grant