Determining the transcriptional programme of a leukaemogenic transcription factor in normal and leukaemic cells [ 2011 - 2013 ]

Research Grant

Researchers: Prof John Pimanda (Principal investigator) ,  Prof Bertie Gottgens ,  Prof Shai Izraeli

Brief description Leukaemic (blood cancer) cells develop from immature blood cells by inappropriate expression of genes. These genes are also those that are required for normal blood production in the embryo. Gene expression during normal blood development is tightly controlled. However in leukaemia, these genes are expressed at inappropriate stages of blood development. We will investigate whether leukaemic cells adopt features of embryonic blood stem cells to express genes that convert normal cells into abnormal cells.

Funding Amount $AUD 643,958.39

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant