grant

Determining the structure of a soluble cytokine receptor complex [ 2006 - 2008 ]

Also known as: Studies of proteins involved in cancer and allergic disease

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/395512]

Researchers: Prof Michael Parker (Principal investigator) ,  Dr Timothy Hercus

Brief description There is a pressing need to develop improved therapeutics to treat many forms of cancer and respiratory diseases. This proposal concerns the biochemical investigation of a group of protein hormones and their associated receptors that are implicated in blood cell cancers and for which current treatments are only partly effective . Our work will focus on determining the 3-dimensional shape and function of this group of proteins in complex with one another which will provide us with an understanding of how these proteins communicate with one another. This information may provide a basis for the design of new drugs that can specifically block the activity of these protein hormones, thereby providing new treatment possibilities for these blood cell cancers.

Funding Amount $AUD 509,017.61

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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