Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/105704]Researchers: Prof Richard Allen (Principal investigator)
Brief description Tight glucose control by insulin injection minimises diabetic complications but restricts lifestyle. An alternative, pancreatic islet transplantation, is limited by donor shortage. With genetic technology, pig donor tissue is a feasible donor source. This project will use an inbred pig colony to assess long term foetal pig islet function in the absence of an immune response. It will outline the genetic characteristics of this pig colony and carefully catalogue the type, number and distribution of endogenous retroviruses within pig genes. It may provide a basis from which new strategies can be developed to overcome rejection. Ultimately a unique Australian resource will be developed which may provide unlimited islets for safe, large-scale transplantation of diabetics before they develop debilitating complications.
Funding Amount $AUD 351,660.03
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 105704
- PURL : https://purl.org/au-research/grants/nhmrc/105704
