grant

Determining the Molecular Basis of Tumour Cell Multidrug Resistance: Structural and Functional Analysis of Breast Cancer Resistance Protein [ 2013 - 2018 ]

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1053624]

Researchers: Dr Aaron Mcgrath (Principal investigator)

Brief description Around 40% of human tumours develop resistance to chemotherapeutic drugs; a trait most commonly acquired by the increased expression of membrane proteins that remove a broad spectrum of molecules from the cell. This project aims to determine the structure of the human breast cancer resistance protein (BCRP), a protein of particular importance in this process. The structure of BCRP will provide a scaffold for the design of drugs aimed at inhibiting chemotherapy drug resistance.

Funding Amount $AUD 359,112.00

Funding Scheme Early Career Fellowships

Notes CJ Martin Biomedical ECF

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Identifiers
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ACN 633 798 857