Determining modes of binding and activation of peptide G-protein coupled receptor targets [ 2014 - 2016 ]

Research Grant

Researchers: Prof Ross Bathgate (Principal investigator) ,  A/Pr Paul Gooley ,  Dr Karl Johan Rosengren

Brief description The neuropeptide relaxin-3 and the peptide hormone INSL5 are recently discovered members of the relaxin peptide family. Relaxin-3 has important roles in stress and feeding whereas INSL5 is a gut hormone. We will study the interaction of relaxin-3 and INSL5 with their cell surface receptors and the mechanisms by which the receptors function. The knowledge gained will aid in the design of smaller, more potent and orally active forms of relaxin-3 and INSL5 for future clinical applications

Funding Amount $AUD 576,538.86

Funding Scheme Project Grants

Notes Standard Project Grant