grant

Determinants of insulin-like growth factor (IGF) binding and biological actions of IGF binding protein-6 [ 2004 - 2006 ]

Also known as: How do different parts of a protein work?

Funded by National Health and Medical Research Council
Managed by Monash University
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/299960]

Researchers: Prof Leon Bach (Principal investigator)

Brief description Proteins are complex structures usually consisting of a number of distinct regions. Each of these regions may serve different roles. Insulin-like growth factors (IGFs) are important proteins involved in regulating the growth and other properties of cells. The actions of IGFs are in turn regulated by a family of binding proteins (IGFBPs). The aim of this project is to determine the range of actions of one of these IGFBPs and which parts of this IGFBP are involved in these actions. This may lead to new treatments for diseases in which cell growth is disturbed e.g. cancer and diabetes.

Funding Amount $AUD 399,750.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Apoptosis | Biomedical and Clinical Sciences | Binding protein | Endocrine therapy | Growth factor regulation | Growth factors | Insulin-like growth factors | Microarrays | Mutagenesis | Nutrition and Dietetics | Nutritional Science | Proliferation | Structure-activity relationships |
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