grant

Determinants of immune restoration disease and persistent immune dysfunction in HIV patients responding to ART [ 2008 - 2010 ]

Also known as: What determines whether a HIV patient responding to ART restores optimal resistance to other infections?

Funded by National Health and Medical Research Council
Managed by The University of Western Australia
Managed by University of Western Australia
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/513755]

Researchers: A/Pr Patricia Price (Principal investigator) ,  Prof Adeeba Kamarulzaman ,  Prof Martyn French

Brief description Many people throughout the world now receive antiretroviral treatment (ART) for HIV-AIDS. ART increases numbers of CD4 T-cells, but does not restore all functions the immune system. In addition, some patients experience serious exacerbations of pre-existing secondary infections when they respond to ART. We were the first to describe these Immune Restoration Diseases and will investigate the underlying mechanisms and the causes of persistent immune deficiency here.

Funding Amount $AUD 445,011.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Clinical Chemistry (Incl. Diagnostics) | Clinical Sciences | HIV pathogenesis | HIV related immune suppression | HIV-AIDS | T cell immunity | combination antiretroviral therapy | cytokine regulation | herpes | immunogenetics | immunopathology | pulmonary tuberculosis |
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