grant

Deregulation of DNA hydroxymethylases Tet1/ Tet2 compromises skeletal integrity during ageing and bone disease [ 2018 - 2021 ]

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1141361]

Researchers: Prof Stan Gronthos (Principal investigator) ,  Dr Melissa Davis Prof Tuan Nguyen

Brief description Epigenetic modifications of DNA and associated proteins regulate gene expression. A greater understanding of the molecular pathways and associated epigenetic changes that regulate bone cell commitment under normal and pathological conditions will help enhance our ability to diagnose and treat disorders/ diseases that effect skeletal tissues through the pharmacological manipulation of epigenetic modifiers and their gene targets.

Funding Amount $AUD 862,131.99

Funding Scheme Project Grants

Notes Standard Project Grant

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