Deregulation of DNA hydroxymethylases Tet1/ Tet2 compromises skeletal integrity during ageing and bone disease [ 2018 - 2021 ]

Research Grant

Researchers: Prof Stan Gronthos (Principal investigator) ,  Dr Melissa Davis ,  Prof Tuan Nguyen

Brief description Epigenetic modifications of DNA and associated proteins regulate gene expression. A greater understanding of the molecular pathways and associated epigenetic changes that regulate bone cell commitment under normal and pathological conditions will help enhance our ability to diagnose and treat disorders/ diseases that effect skeletal tissues through the pharmacological manipulation of epigenetic modifiers and their gene targets.

Funding Amount $AUD 862,131.99

Funding Scheme Project Grants

Notes Standard Project Grant