Dengue virus NS1 protein as a mediator of pathology [ 2016 - ]

Research Grant

Researchers: A/Pr Katryn Stacey (Principal investigator) ,  Dr Daniel Watterson ,  Dr David Muller ,  Prof Paul Young

Brief description Dengue virus is an increasing problem in the tropical world, with estimated infection of more than 300 million people annually. Severe dengue disease can cause life-threatening bleeding and shock. Our project investigates the basis for the pathology of the disease. We have found that a viral protein termed NS1 binds to a receptor on immune cells and leads to production of inflammatory proteins which can promote vessel leakage. We will investigate drugs blocking this, in a disease model.

Funding Amount $621,979.00

Funding Scheme Project Grants

Notes Standard Project Grant