delta-containing GABA-A receptors as targets for neuroprotection [ 2015 - 2019 ]

Research Grant

Researchers: Prof Mary Collins Chebib (Principal investigator) ,  A/Pr Thomas Balle ,  Dr Andrew Clarkson ,  Dr Christopher Vaughan ,  Dr Joseph Nicolazzo
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Brief description After stroke, the neurotransmitter, GABA spills onto sites located away from the synapse. This spillover is hypothesised to have a protective role in limiting cell death. However the timeframe for this to occur is too long for observing significant beneficial effects after stroke. Therefore, stimulating this naturally occurring protective mechanism early using pharmaceutical interventions that target a specific type of GABAA receptor is an unexplored strategy to minimize cell death after stroke.

Funding Amount $AUD 953,825.49

Funding Scheme Project Grants

Notes Standard Project Grant