grant

Delineation of receptor-activated conformational signalling pathways in HIV-1 envelope glycoproteins [ 2008 - 2010 ]

Also known as: Receptor activated conformational changes in HIV-1 gp120 and gp41.

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/488204]

Researchers: Dr Pantelis Poumbourios (Principal investigator) ,  A/Pr Heidi Drummer Prof Paul Gorry

Brief description Although antiretroviral therapy has prolonged the life of people infected with HIV, the virus rapidly develops resistance. Therefore it is essential to develop new antiviral agents to combat HIV infection. The first stages of infection include the process of the virus attaching to cellular receptors and the fusion of viral and cellular membranes leading to entry. In this project we seek to understand how the surface proteins of the virus mediate viral entry and identify new antiviral targets.

Funding Amount $AUD 834,478.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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