Delineating the interaction between the Amyloid Precursor Protein family and sorLA-LR11 [ 2008 - 2011 ]

Research Grant

Researchers: Prof Roberto Cappai (Principal investigator) ,  Dr Olav Andersen

Brief description The Alzheimer's disease Amyloid Precursor Protein (APP) is central to the cause of Alzheimer's disease (AD). It's metabolised into the neurotoxic amyloid beta (Abeta) peptide that is deposited in AD brains. The sorLA protein is a neuronal protein that interacts with APP and alters its metabolism into Abeta. This grant will study the interaction between APP and sorLA and define the APP binding site for sorLA which represents a potential drug target.

Funding Amount $AUD 749,021.98

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant