Data

Defining the roles of NADPH oxidases in vascular remodelling and atherosclerosis: data

Monash University
Assoc Prof Christopher Sobey (Associated with) Dr Alyson Miller (Associated with) Dr Courtney Judkins (Associated with) Dr Grant Drummond (Aggregated by) Dr Stavros Selemidis (Associated with)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=1959.1/289117&rft.title=Defining the roles of NADPH oxidases in vascular remodelling and atherosclerosis: data&rft.identifier=1959.1/289117&rft.publisher=Monash University&rft.description=Researchers from Monash University (Grant Drummond, Christopher Sobey, Courtney Judkins, Henry Diep, Brad Broughton, Elizabeth Hooker, Alyson Miller, Stavros Selemidis) and the Howard Florey Institute (Greg Dusting) experimented on mice to test the hypothesis that upregulation of one enzyme (from a family of enzymes called NADPH oxidases) in the early stages of hypertension, is the initial trigger for many of the downregulation effects that ultimately lead to cardiovascular disease. Machine generated data, including flow cytometry, realtime PCR (Polymerase Chain Reaction) and FACS (Florescence Activated Cell Sorting) collected on blood plaque and blood pressure in mice was analysed to develop a better understanding of cause and prevention of heart attacks and strokes. The data revealed the underlying problem of atherosclerosis in blood vessels, the build up of fatty plaques which may close arteries or grow and rupture and the role of oxy-radicals and free-radicals in this build up of plaque. The enzyme NOX2 was identified as the probable cause. &rft.creator=Dr Grant Drummond&rft.date=2012&rft.relation=10.1152/ajpheart.00799.2009 &rft.relation=10.1161/STROKEAHA.109.575365&rft_subject=Basic Pharmacology&rft_subject=MEDICAL AND HEALTH SCIENCES&rft_subject=PHARMACOLOGY AND PHARMACEUTICAL SCIENCES&rft_subject=Cardiology (incl. Cardiovascular Diseases)&rft_subject=CARDIORESPIRATORY MEDICINE AND HAEMATOLOGY&rft_subject=NADPH oxidase&rft_subject=Superoxide&rft_subject=Oxidative stress&rft_subject=Endothelial dysfunction&rft_subject=Atherosclerosis&rft_subject=Nicotinamide adenine dinucleotide phosphate (reduced)&rft_subject=Arterial hypertension&rft.type=dataset&rft.language=English Access the data
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Researchers from Monash University (Grant Drummond, Christopher Sobey, Courtney Judkins, Henry Diep, Brad Broughton, Elizabeth Hooker, Alyson Miller, Stavros Selemidis) and the Howard Florey Institute (Greg Dusting) experimented on mice to test the hypothesis that upregulation of one enzyme (from a family of enzymes called NADPH oxidases) in the early stages of hypertension, is the initial trigger for many of the downregulation effects that ultimately lead to cardiovascular disease. Machine generated data, including flow cytometry, realtime PCR (Polymerase Chain Reaction) and FACS (Florescence Activated Cell Sorting) collected on blood plaque and blood pressure in mice was analysed to develop a better understanding of cause and prevention of heart attacks and strokes. The data revealed the underlying problem of atherosclerosis in blood vessels, the build up of fatty plaques which may close arteries or grow and rupture and the role of oxy-radicals and free-radicals in this build up of plaque. The enzyme NOX2 was identified as the probable cause.

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100 spreadsheets (xls, 5000 kb): 100 Graph Pad Prism files (2000 kb) : powerpoint files (.ppt, 800kb)

Data time period: 2005

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Subjects
Arterial hypertension | Atherosclerosis | Basic Pharmacology | Cardiorespiratory Medicine and Haematology | Cardiology (Incl. Cardiovascular Diseases) | Endothelial dysfunction | Medical and Health Sciences | NADPH oxidase | Nicotinamide adenine dinucleotide phosphate (reduced) | Oxidative stress | Pharmacology and Pharmaceutical Sciences | Superoxide |

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Identifiers
ACN 633 798 857