Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity. [ 2018 - 2020 ]

Research Grant

Researchers: A/Pr Natasha Harvey (Principal investigator) ,  Dr Samir Taoudi ,  Prof Hamish Scott

Brief description The precise spatial and temporal control of gene expression is regulated by non-coding regions of the genome termed enhancers. Enhancers are crucial to program cell identity and have established roles in development and disease. We have identified a novel enhancer that we hypothesise controls the identity of valve endothelial cells by regulating expression of a master programmer of lymphatic endothelial cell identity, PROX1. Here we will investigate the role of this enhancer during development.

Funding Amount $AUD 706,909.48

Funding Scheme Project Grants

Notes Standard Project Grant