Defining the role of GATA2 in lymphatic vascular development as a means to understanding how GATA2 mutations predispose to human lymphedema. [ 2014 - 2016 ]

Research Grant

Researchers: A/Pr Natasha Harvey (Principal investigator) ,  Prof Hamish Scott

Brief description We have discovered that mutations in the transcription factor GATA2 result in human primary lymphedema, a debilitating disorder resulting from the failure of lymphatic vessels to return tissue fluid to the bloodstream. The goal of this application is to define the role of GATA2 in lymphatic vessels, in order to understand how GATA2 mutations cause lymphedema. Ultimately, we aim to identify targets to which desperately needed therapeutics for the treatment of lymphedema could be generated.

Funding Amount $AUD 718,890.89

Funding Scheme Project Grants

Notes Standard Project Grant