Defining the pathways for the import of proteins into mitochondria [ 2002-01-01 - 2005-01-23 ]

Research Grant

Researchers: Michael Ryan (Chief Investigator) ,  Prof Nicholas Hoogenraad (Chief Investigator) ,  Prof F-Ulrich Hartl (Partner Investigator)

Brief description Defining the pathways for the import of proteins into mitochondria. This application deals with the targeting of preproteins from the cytosol to the mitochondria in mammalian cells. The aims are to identify and characterise mitochondrial targeting signals within preproteins lacking typical N-terminal signal sequences; to characterise the roles of the cytosolic molecular chaperones such as Hsp90 and Hsp70 in assisting the movement of preproteins to the mitochondrial surface; to determine the interactions of both preproteins and cytosolic factors with outer membrane components and; to analyse the roles of individual TOM receptors in import. The results obtained will facilitate our understanding of general protein import processes and those specific for mammals.

Funding Amount $180,000

Funding Scheme Discovery Projects

View this grant in the ARC Data Portal