Defining the Myb-p300 dependent transcriptional program in myeloid leukaemia [ 2012 - 2015 ]

Research Grant

Researchers: Prof Thomas Gonda (Principal investigator) ,  Dr Brooke Gardiner ,  Dr Evgeny Glazov

Brief description MYB is a “cancer gene” which turns other genes on or off. MYB is needed by leukaemia cells but also for normal blood cell formation. We have found that interaction between the MYB protein and a protein called p300 is more critical for growth of leukaemia cells than for normal cells. Here we aim to identify a set of MYB/p300 co-regulated genes that are needed by leukaemia cells for the continued growth or survival. Some of these genes may be targets for developing new leukaemia drugs.

Funding Amount $AUD 603,631.97

Funding Scheme Project Grants

Notes Standard Project Grant