Defining the mechanisms of action for ozonide antimalarials [ 2017 - 2019 ]

Research Grant

Researchers: Dr Darren Creek (Principal investigator) ,  Prof Susan Charman

Brief description Deadly malaria parasites have emerged that are resistant to all classes of approved drugs. Ozonides are a new class of medicines recently approved for malaria, and provide a much-needed treatment option for multi-drug resistant infections. However, the mode of action and potential for cross-resistance is poorly understood. This project will use modern analytical techniques to measure the impact of ozonides on parasite biochemistry to reveal mechanisms involved in drug action and resistance.

Funding Amount $AUD 683,876.86

Funding Scheme Project Grants

Notes Standard Project Grant