grant

Defining the leukaemogenic mechanism for GATA2 T354M, a new predisposing mutation in familial MDS/AML [ 2011 - 2014 ]

Also known as: GATA2 is a new predisposition gene for familial AML

Funded by National Health and Medical Research Council
Managed by University of Adelaide
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1002317]

Researchers: Prof Hamish Scott (Principal investigator) ,  Dr Christopher Hahn ,  Prof Junia Vaz De Melo ,  Prof Richard D'Andrea

Brief description A successful approach for identification of cancer genes has been to study the 5-10% of cases occurring in families with inherited predisposition to develop cancer. Unlike solid tumours, few cancer-causing mutations are known for haematological cancers. We have found a new mutation in 3 families in a gene (GATA2) not previously associated with familial acute myeloid leukaemia. We will explore how this mutation causes leukaemia to help better understand the more common non-inherited leukaemias.

Funding Amount $AUD 631,883.62

Funding Scheme Project Grants

Notes Standard Project Grant

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Related Publications

  • Associated with Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia
    handle : 2440/94961

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Subjects
Haematological Tumours | Medical and Health Sciences | Oncology and Carcinogenesis | genetic predisposition | haematological malignancy | haematopoiesis | inherited | leukaemia | molecular genetics | mutation analysis | myelopoiesis | transcription factor |
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