Defining the changes in cell biology caused by PRESENILIN truncations associated with different diseases [ 2014 - 2017 ]

Research Grant

[Cite as]

Researchers: A/Pr Michael Lardelli (Principal investigator) ,  Dr Morgan Newman

Brief description Truncations of the PRESENILIN genes in humans can cause two very different diseases: inherited, early onset Alzheimer’s disease (familial Alzheimer's disease) and a skin disease named inherited Acne Inversa. One truncation is also involved in the non-inherited, late onset form of Alzheimer’s disease. Why do these different truncations produce different diseases? Investigating this question will teach us more about the molecular bases of these different diseases. This understanding will be required for the development of treatments.

Funding Amount $AUD 622,886.08

Funding Scheme Project Grants

Notes Standard Project Grant

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