grant

Defining the cellular impacts of protein aggregation in neurodegenerative disease with an aggreomics platform [ 2012 - 2016 ]


Funded by Australian Research Council
Managed by University of Melbourne
Provided by   Australian Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/arc/FT120100039]

Researchers Dr Daniel Hatters

Brief description The brain disease Huntington’s is caused by abnormally shaped proteins that assemble into toxic clusters. This project will design new bioprobes to track how these clusters form and cause damage to cells. This strategy will also provide new opportunities for discovering novel therapeutic targets.

Funding Amount 707628

Funding Scheme Future Fellowships

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Related Publications

  • Associated with Polyalanine expansions drive a shift into alpha-helical clusters without amyloid-fibril formation
    URI : http://hdl.handle.net/11343/57364
  • Associated with Walking the tightrope: Proteostasis and neurodegenerative disease.
    URI : http://hdl.handle.net/11343/58706

Related Organisations

Subjects
Biochemistry and Cell Biology | Biological Sciences | huntington's disease | protein aggregation | protein misfolding |
Identifiers
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