Defective toll-like receptor 7 signalling in plasmacytoid dendritic cells underlies the inception of virus-associated asthma [ 2012 - 2015 ]

Research Grant

Researchers: A/Pr Simon Phipps (Principal investigator) ,  Prof John Upham

Brief description In genetically susceptible individuals, respiratory virus infections are a risk factor for asthma inception and are the most common cause of acute exacerbations. Using a clinically relevant mouse model of disease, this study will investigate whether the altered expression of toll-like receptor 7, a host protein that senses viral invasion, causes the host to mount an inappropriate pro-allergic immune response to the virus.

Funding Amount $AUD 552,301.03

Funding Scheme Project Grants

Notes Standard Project Grant