Toward a deeper understanding of new DNA modifications in fear-related learning. [ 2019 - ]

Research Grant

Brief description The goal of this project is to test the hypothesis that a recently discovered chemical modification on DNA represents an important new mechanism for the control of gene expression underlying fear-related learning and memory. Specifically, we propose that the experience-dependent accumulation of m6dA, through direct effects on DNA structure, protein binding and epigenetic state, is necessary for activity- or learning-induced gene expression and required for fear extinction memory.

Funding Amount $666,876.00

Funding Scheme Project Grants

Notes Standard Project Grant