Deciphering how TCR affinity regulates CD4 T cell help in immunity and autoimmunity [ 2018 - 2020 ]

Research Grant

Researchers: Dr Patrick Bertolino (Principal investigator) ,  A/Pr Carl Feng ,  A/Pr David Bowen ,  A/Pr Raymond Steptoe

Brief description Immune responses require the coordinated interaction and cross-talk between two types of white blood cells known as CD4 and CD8 T cells. A dysregulated interaction between these cells could be the cause of autoimmune and persistent infections by pathogens leading to chronic diseases. The aim of this proposal is to provide a deeper understanding of CD4/CD8 T cell interactions to improve immune outcomes in many chronic diseases in which interaction between these two immune cells is critical.

Funding Amount $AUD 850,885.92

Funding Scheme Project Grants

Notes Standard Project Grant