Deciphering the role of DNA methylation in the regulation of alternative splicing [ 2017 - 2020 ]

Research Grant

Researchers: Prof Ryan Lister (Principal investigator) ,  Dr Justin Wong ,  Prof John Rasko

Brief description When a gene is turned on, the messenger RNA must be correctly processed to generate functional proteins. This ‘splicing’ process is essential for normal cellular activity, and is disrupted in many human diseases. We have discovered that an epigenetic modification, DNA methylation (mC), may control splicing. This project will investigate how mC influences splicing and use new epigenome-editing tools to control it, in order to ultimately understand and treat diseases involving aberrant splicing.

Funding Amount $AUD 885,785.18

Funding Scheme Project Grants

Notes Standard Project Grant