Deciphering the overlapping roles of SSB1 and SSB2 in the regulation of haematopoiesis and intestinal homeostasis [ 2015 - 2018 ]

Research Grant

Researchers: Prof Kum Kum Khanna (Principal investigator) ,  A/Pr Steven Lane ,  Prof Robert Ramsay

Brief description Our work centres on elucidating the role of two newly identified and related single-stranded DNA binding protein (Ssb1 and Ssb2) in development of blood and gut system. When both genes are deleted mice die with 8 days of knockdown due to bone marrow failure and intestinal atrophy. Our double knockout model parallels the consequences of radiation damage on blood and gut system. Toxicity to these systems is a significant hindrance in delivering anti-tumor therapy.

Funding Amount $AUD 996,631.12

Funding Scheme Project Grants

Notes Standard Project Grant