grant

Deciphering the Neuroprotective Mechanism of Parkinsons Disease-Associated Protein Kinase PINK1 [ 2009 - 2011 ]

Also known as: How does inactivation of PINK1 cause Parkinsons disease?

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/566751]

Researchers: A/Pr Heung-Chin Cheng (Principal investigator) ,  Dr Janetta Culvenor ,  Dr Kip Gabriel

Brief description Parkinson's disease is caused by premature death of nerve cells that control body movements. The enzyme PINK1 protects against nerve cell death by chemically modifying specific cellular proteins that maintain cell survival. We aim at identifying these proteins and investigating how PINK1-catalysed modification modulates their ability to maintain nerve cell survival. The study will benefit development of drugs that protect against nerve cell death for treatment and prevention of the disease.

Funding Amount $AUD 547,994.78

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Medical Infection Agents (Incl. Prions) | Medical Microbiology | Mitochondria | Neuronal death | Parkinson'a disease | Parkinson's disease | Pathogenic mechanism | Protein kinases | degeneartive disease of the CNS | neurodegeneration | neurodegenerative diseases | oxidative stress and apoptosis |
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