Deciphering IFN type III, TGFβ, IL-10 and adenosine pathways in natural killer cells: enhancing the innate anti-metastatic response against breast cancer progression [ 2015 - ]

Research Grant

Researchers: Dr Fernando de Souza Fonseca Guimaraes (Principal investigator)

Brief description This project will determine whether one or more factors produced in tumours (eg. cell hormones and metabolites) inhibits NK cells from controlling breast cancer spread using the best available mouse tumour models. We will use genetics to specifically delete response to these factors by NK cells. It is a completely novel approach and this information will allow for the more rational design of cancer treatments following surgery and local radiotherapy and/or chemotherapy.

Funding Amount $309,436.00

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF