Deciphering the function of caspase-2 in DNA damage response and tumour suppression [ 2013 - 2017 ]

Also known as: Study of a novel tumour suppressor protein

Research Grant

[Cite as]

Researchers: Prof Sharad Kumar (Principal investigator) ,  Dr Loretta Dorstyn

Brief description Aberrant cell death and DNA damage response (DDR) are hallmarks of tumourigenesis. Recently we have discovered that an enzyme, caspase-2, previously implicated in cell death execution, also works in DDR and acts as a tumour suppressor. We now wish to validate these finding in preclinical models of cancer and understand precisely how caspase-2 safeguards against cancer development. These studies will help better understand tumourigenesis and may lead to the discovery of new drug targets.

Funding Amount $AUD 808,007.66

Funding Scheme Project Grants

Notes Standard Project Grant

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