Cytosolic oxidative disturbances as a source of mitochondrial dysfunction in diabetic nephropathy [ 2009 - 2011 ]

Research Grant

Researchers: Prof Josephine Forbes (Principal investigator) ,  A/Pr Judy De Haan ,  Prof David Thorburn ,  Prof Gerald Muench ,  Prof Michael Stowasser (Funded by)

Brief description There is a critical need to identify new therapies for the growing number of patients with diabetic kidney disease. Current medicines only retard progressive disease. Our studies investigate defects in the power houses of the cell, the mitochondria. These defects cause generation of toxic free oxygen radicals which eventually starve the cell of energy production. Therefore, reversal of mitochondrial defects in diabetic kidney disease may be a novel therapeutic target.

Funding Amount $AUD 505,786.13

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant