Cytoskeletal regulation of platelet adhesion and thrombus formation [ 2001 - 2003 ]

Research Grant

Researchers: Prof Hatem Salem (Principal investigator) ,  Dr Susan Cranmer

Brief description Platelets are small specialised blood cells that are essential for normal blood clotting and repair of damaged blood vessels following injury. When platelets stick to sites of blood vessel injury they undergo dramatic changes in their shape and internal structure that are necessary for these cells to spread over the damaged surface and facilitate the formation of a stable blood clot. We are studying these changes in the intracellular structure (cytoskeleton) of platelets and how these events might regulate the reactivity of platelets and their ability to adhere to blood vessels. An understanding of these processes will add significantly to our knowledge of how blood clots. This information is relevant to many human diseases such as heart attack and stroke.

Funding Amount $AUD 406,527.54

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant