grant

Cytoplasmic DNA as a danger signal for mammalian cells [ 2010 - 2012 ]

Also known as: Stray DNA in mammalian cells signals an infection

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/631472]

Researchers: A/Pr Katryn Stacey (Principal investigator) ,  Dr Tara Roberts Prof Matthew Sweet

Brief description DNA in mammalian cells is contained within a structure known as the nucleus. The presence of DNA outside the nucleus in the cytoplasm of the cell is a sure sign that something is wrong, and may indicate the presence of a viral invader. In this case, the cell initiates anti-viral responses, including production of anti-viral proteins and death of the infected cell to stop replication of the virus. Lack of proper control of these responses may contibute to the autoimmune disease lupus.

Funding Amount $AUD 592,661.13

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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