Cytokine responses within the GI tract dictate T cell fate and transplant outcome [ 2018 - 2021 ]

Research Grant

Researchers: Prof Geoff Hill (Principal investigator) ,  A/Pr Ashraful Haque ,  Dr Antiopi Varelias ,  Prof Bruce Blazar ,  Prof Michael Mcguckin

Brief description Over 10,000 persons per year in Australia are diagnosed with a blood cancer, accounting for 10% of cancer deaths. Stem cell transplantation remains curative therapy for these diseases but is limited by a process known as graft-versus-host disease (GVHD), responsible for mortality in up to 50% of patients. This project will focus on immune responses within the colon as the critical event initiating lethal GVHD, defining new treatments that will be translated to improve transplant outcomes.

Funding Amount $AUD 1,479,579.12

Funding Scheme Project Grants

Notes Standard Project Grant