Cytokine and macrophage determinants of pulmonary inflammation during tuberculosis [ 2009 - 2011 ]

Research Grant

Researchers: Dr Bernadette Saunders (Principal investigator) ,  Prof Georges Grau ,  Prof Warwick Britton

Brief description Tuberculosis (TB) infects 33% of the world, causing over 2 million deaths per year. TB disease causes damaging lung pathology and new therapies to treat the infection and moderate inflammation are urgently required. TNF is essential for immunity to TB, acting to modulate inflammation. This grant will determine how soluble and membrane- bound TNF regulate the cellular and cytokine control of TB pathology and may lead to new therapies to limit inflammation in TB and other inflammatory diseases.

Funding Amount $AUD 455,899.19

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant