Cytokine Inhibition as a Potential Therapy for ANCA-Associated Glomerulonephritis [ 2017 - ]

Research Grant

Researchers: Prof Stephen Holdsworth (Principal investigator) ,  Prof Arthur Kitching

Brief description MPO-ANCA associated glomerulonephritis is a major cause of renal failure. Current treatments are toxic and poorly effective. Cytokines are immune proteins that direct disease. New biological anti-cytokine treatments are effective but not available for kidney diseases. This study will define the key cytokines driving this disease and provide proof of safety and efficacy in our animal model of this disease. This evidence will allow the introduction of anti-cytokine biologicals in clinical trials.

Funding Amount $929,596.00

Funding Scheme Project Grants

Notes Standard Project Grant