Cytokine-driven allergic inflammation: characterization of two isoform-specific modes of IL-3 receptor activation and investigation of new receptor-associated signalling partners. [ 2012 - 2015 ]

Also known as: The molecular details of how the cytokine, interleukin-3, activates its receptor and promotes allergic inflammation

Research Grant

[Cite as]

Researchers: Prof Ian Young (Principal investigator) ,  A/Pr James Murphy Prof David Ollis

Brief description In asthma, the symptoms are caused by an allergic reaction in the lung orchestrated by immune cells which produce small proteins called cytokines thus stimulating inflammatory cell production. The cytokine IL-3 is critical for the production of basophils which have an important role in the inflammation. The project will investigate the molecular details of how the IL-3 binds to its receptor and stimulates basophil production and reveal new targets for controlling inflammation in asthma.

Funding Amount $AUD 620,716.41

Funding Scheme Project Grants

Notes Standard Project Grant

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