grant

Cytochrome P450-mediated epoxides of polyunsaturated fatty acids that regulate cell death and survival [ 2009 - 2012 ]

Also known as: Fatty acid metabolites that protect or kill cells

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/570933]

Researchers: Prof Michael Murray (Principal investigator)

Brief description Omega-3 polyunsaturated fatty acids (PUFAs) decrease cancer risk in man whereas omega-6 PUFA, which are common in western diets, increase risk. In cells cytochrome P450 converts PUFAs to epoxides. Omega-6 epoxides stimulate growth of cells and tumours but we have found that epoxides of the omega-3 eicosapentaenoic acid inhibit cell growth. We will now evaluate the mechanisms of these effects, which could lead to new anticancer treatments, perhaps based on altered diet.

Funding Amount $AUD 495,710.84

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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